WP1: Carbohydrate production

The training in WP1 Carbohydrate production builds on the strong UL background in carbohydrate chemistry directed to liquid and solid phase carbohydrate synthesis and analytics of small glycans, as witnessed by the large publication record in carbohydrate synthesis of various bacterial glycan structures from Staphylococcus aureus, Group A Streptococcus, P. aeruginosa, where GSK will provide its historical expertise in polysaccharide purification/isolation/characterization. It will train the ESRs in the chemical modification of proteins, which has been applied to develop a series of commercially available vaccines against H. influenzae type b, S. pneumoniae, N. meningitidis, and candidates at preclinical or clinical level (e.g. Group B Streptococcus, Candida albicans, Clostridium difficile).